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(-)-Epigallocatechin Gallate

Name: (-)-Epigallocatechin Gallate
SKU: 0

(-)-Epigallocatechin Gallate
CAS No.: 989-51-5
Molecular Formula: C22H18O11
Molecular Weight: 458.37

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PRODUCT DESCRIPTION

(-)-epigallocatechin 3-gallate is a gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. It has a role as an antineoplastic agent, an antioxidant, a Hsp90 inhibitor, a neuroprotective agent, a plant metabolite, a geroprotector and an apoptosis inducer. It is a gallate ester, a polyphenol and a member of flavans. It is functionally related to a (-)-epigallocatechin.

Chemical Properties

Property	Value
Melting point	222-224°C
Alpha	D -185 ±2°(ethanol)
Refractive index	-175.5 ° (C=1, EtOH)
Storage temp.	2-8°C
Solubility	H2O: ≥5mg/mL, clear
Form	Solid
Boiling point	909.1±65.0 °C(Predicted)
Density	1.90±0.1 g/cm3(Predicted)
PKa	7.75±0.25(Predicted)
Color	White to Light Brown
Biological source	Green tea
Water Solubility	Soluble in ethanol, dimethyl formamide, water.
Merck	14,3526
Stability	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey	WMBWREPUVVBILR-WIYYLYMNSA-N
LogP	0.639 (est)
CAS DataBase Reference	989-51-5(CAS DataBase Reference)

Safety Information

Property	Value
Safety Statements	24/25
WGK Germany	2
RTECS	KB5200000
F	10-23
HS Code	29339900
Toxicity	LD50 oral in mouse: 2170mg/kg

Product Usage

(-)-Epigallocatechin gallate (EGCG), the most abundant and potent catechin found in green tea, is a world-renowned antioxidant widely utilized in the nutraceutical and functional food industries. It is a primary active ingredient in dietary supplements aimed at weight management, metabolic support, and cardiovascular protection. In the cosmetic and dermo-pharmaceutical sector, EGCG is highly prized for its anti-inflammatory and photoprotective properties, often incorporated into high-end skincare formulations to prevent UV-induced damage and slow the signs of aging. Beyond consumer goods, it plays a vital role in biomedical research, where it is studied for its potential in cancer prevention and its ability to inhibit protein misfolding in neurodegenerative diseases. Additionally, its natural antimicrobial properties make it an effective food preservative, helping to extend shelf life and maintain the nutritional integrity of processed oils and fats.

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