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Trifluoroacetamide

Name: Trifluoroacetamide
SKU: 0

Trifluoroacetamide
CAS No.: 354-38-1
Molecular Formula: C2H2F3NO
Molecular Weight: 113.039

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PRODUCT DESCRIPTION

Trifluoroacetamide has a melting point of approximately 72-75℃ and a boiling point of about 162-164℃. It is readily soluble in water, ethanol, ether and other polar organic solvents. It possesses the typical chemical properties of amide compounds. Meanwhile, due to the presence of trifluoromethyl (-CF₃), it has certain stability and special reactivity. For instance, in organic synthesis, it can be used as an acylation reagent or a protecting group.

Chemical Properties

Property	Value
Melting point	65-70 °C (lit.)
Boiling point	162.5 °C (lit.)
Density	1.4176 (estimate)
Bulk density	960kg/m3
Fp	162-164°C
Storage temp.	Store below +30°C.
Solubility	460 g/L (20°C)
Pka	12.33±0.50(Predicted)
Form	Crystalline Powder or Crystals
Color	White to pale yellow or beige
PH	3.6 (460g/l, H2O, 23℃)
Water Solubility	460 g/L (20 ºC)
BRN	1753625
InChIKey	NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP	0.725 at 23℃ and pH4.83
Dissociation constant	0 at 23℃
CAS DataBase Reference	354-38-1(CAS DataBase Reference)
NIST Chemistry Reference	Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System	Acetamide, 2,2,2-trifluoro- (354-38-1)

Safety Information

Property	Value
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
RIDADR	1759
WGK Germany	3
Hazard Note	Harmful/Irritant
TSCA	T
HazardClass	8
PackingGroup	III
HS Code	29241900

Product Usage

Trifluoroacetamide is a specialized fluorinated intermediate widely utilized in high-end organic synthesis. Its primary application is in the pharmaceutical industry, where it serves as a critical building block for introducing trifluoromethyl groups into bioactive molecules, enhancing their metabolic stability and lipophilicity. In agrochemical manufacturing, it is an essential precursor for synthesizing high-efficiency herbicides, insecticides, and fungicides. Furthermore, it acts as a versatile protecting group reagent in peptide synthesis and organic chemical reactions. In the field of material science, trifluoroacetamide is employed in the development of fluorinated polymers and specialty electronic chemicals, valued for their unique dielectric properties and thermal resistance.

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Inventory 2-3 working days New manufacturing 7-10 working days

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